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Key Points The drugs that were known to be effective for the treatment of depression during the 1960s and 1970s were inhibitors of monoamine oxidase, which degraded the monoamines, or tricyclic antidepressants, which inhibited the uptake of monoamines

Clinically, sputum is used as a surrogate for lower airway samples

There is nothing to worry about as it commonly occurs among many people

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This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice